Exercising neuronal organoids
Neuronal organoids are a valuable model for investigating human neurons. It still needs to be determined how these preparations will best facilitate discoveries in fundamental neuroscience or accelerate the process of drug discovery.
We genetically enhance human neurons derived from human induced pluripotent stem cells (hiPSCs) with bioengineered sensors and optogenetic or pharmacogenetic actuators. This platform enables us to control activation patterns in a closed loop, allowing us to study their impact on neuronal organoid development and function. Furthermore, these preparations allow us to definitively evaluate the effects of gene editing and neuromodulatory drugs.
More Details:
Publication:
Kopic, I. et al. Inkjet-Printed 3D Electrode Arrays for Recording Signals from Cortical Organoids. Advanced Materials Technologies 2400645 (2024). https://doi.org/10.1002/admt.202400645
References:
https://www.helmholtz-munich.de/en/isbm
https://www.helmholtz-munich.de/en/core-facility-overview/induced-pluripotent-stem-cells/research-groups/organoids
Contact
Gil Westmeyer
Helmholtz Munich
E-Mail